Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome

@inproceedings{Huang2014HumanTT,
  title={Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome},
  author={Yan Yan Shery Huang and Alberto Hidalgo-Bravo and Enjie Zhang and Victoria E. Cotton and Aar{\'o}n M{\'e}ndez-Berm{\'u}dez and Gunjan Wig and Zahara Medina-Calzada and R. K. Neumann and Alec John Jeffreys and Bruce Winney and James F Wilson and Duncan A. Clark and Martin J.S Dyer and Nicola Jane Royle},
  booktitle={Nucleic acids research},
  year={2014}
}
Linear chromosomes are stabilized by telomeres, but the presence of short dysfunctional telomeres triggers cellular senescence in human somatic tissues, thus contributing to ageing. Approximately 1% of the population inherits a chromosomally integrated copy of human herpesvirus 6 (CI-HHV-6), but the consequences of integration for the virus and for the telomere with the insertion are unknown. Here we show that the telomere on the distal end of the integrated virus is frequently the shortest… CONTINUE READING
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