Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

@article{Broccoli1997HumanTC,
  title={Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2},
  author={Dominique Broccoli and Agata Smogorzewska and Laura Chong and Titia de Lange},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={231-235}
}
Human telomeres are composed of long arrays of TTAGGG repeats that form a nucleoprotein complex required for the protection and replication of chromosome ends. One component of human telomeres is the TTAGGG repeat binding factor 1 (TRF1), a ubiquitously expressed protein, related to the proto-oncogene Myb, that is present at telomeres throughout the cell cycle1–6. Recent evidence has implicated TRF1 in the control of telomere length7. TRF1 is proposed to be an inhibitor of telomerase, acting in… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS