Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.

@article{Lee2003HumanTR,
  title={Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.},
  author={Suzanne Rebecca Lee and Judy M. Y. Wong and Kathleen Collins},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={52531-6}
}
The reverse transcriptase telomerase copies an internal RNA template to synthesize telomeric simple-sequence repeats. In the cellular context, telomerase must elongate its few intended substrates (authentic chromosome ends) without spurious activity on other potential substrates (chromosome ends created by damage, repair, or recombination). Many mechanisms have been proposed to account for the biological substrate specificity of telomerase, with most models focusing on protein-protein… CONTINUE READING

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The reverse transcriptase telomerase copies an internal RNA template to synthesize telomeric simple - sequence repeats .
We used in vivo reconstitution to assemble telomerase enzymes with variant telomerase reverse transcriptase proteins .
We used in vivo reconstitution to assemble telomerase enzymes with variant telomerase reverse transcriptase proteins .
The reverse transcriptase telomerase copies an internal RNA template to synthesize telomeric simple - sequence repeats .
We used in vivo reconstitution to assemble telomerase enzymes with variant telomerase reverse transcriptase proteins .
The reverse transcriptase telomerase copies an internal RNA template to synthesize telomeric simple - sequence repeats .
We used in vivo reconstitution to assemble telomerase enzymes with variant telomerase reverse transcriptase proteins .
The reverse transcriptase telomerase copies an internal RNA template to synthesize telomeric simple - sequence repeats .
Our findings suggest that non - template interactions of the telomerase ribonucleoprotein with telomeric DNA play a critical role in supporting telomerase function on its appropriate cellular substrates .
Our findings suggest that non - template interactions of the telomerase ribonucleoprotein with telomeric DNA play a critical role in supporting telomerase function on its appropriate cellular substrates .
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