Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.

@article{Zhang2012HumanTR,
  title={Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.},
  author={Yong Zhang and LingLing Toh and Peishan Lau and Xueying Wang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 39},
  pages={32494-511}
}
Telomerase activation plays a critical role in human carcinogenesis through the maintenance of telomeres, but the activation mechanism during carcinogenesis remains unclear. The human telomerase reverse transcriptase (hTERT) promoter has been shown to promote hTERT gene expression selectively in tumor cells but not in normal cells. Deregulation of the Wnt/β-catenin signaling pathway is reported to be associated with human carcinogenesis. However, little is known about whether the Wnt/β-catenin… CONTINUE READING
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