Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

@inproceedings{Sharma2012HumanTA,
  title={Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria},
  author={Nilesh Kumar Sharma and Aurelio de los Reyes and Paula Patricia Green and Matthieu J. Caron and Marcelo Gialluisi Bonini and D M Gordon and Ian Holt and Janine Hertzog Santos},
  booktitle={Nucleic acids research},
  year={2012}
}
Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucleoids and tRNAs. We demonstrate the canonical nuclear RNA [human telomerase RNA (hTR)] is not present in human mitochondria and not required for the mitochondrial effects of telomerase, which… CONTINUE READING
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Mitochondrial localization of hTERT as a determinant for hydrogen peroxide-induced mtDNA damage and apoptosis

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