Human susceptibility and resistance to Norwalk virus infection

@article{Lindesmith2003HumanSA,
  title={Human susceptibility and resistance to Norwalk virus infection},
  author={Lisa C. Lindesmith and Christine L. Moe and S{\'e}verine Marionneau and Nathalie Ruvoen and Xi Jiang and Lauren Lindblad and Paul W Stewart and Jacques Lependu and Ralph S. Baric},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={548-553}
}
Infectious diseases have influenced population genetics and the evolution of the structure of the human genome in part by selecting for host susceptibility alleles that modify pathogenesis. [...] Key Result Using a human challenge model, we showed that 29% of our study population was homozygous recessive for the α(1,2)fucosyltransferase gene (FUT2) in the ABH histo-blood group family and did not express the H type-1 oligosaccharide ligand required for Norwalk virus binding.Expand
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