Human susceptibility and resistance to Norwalk virus infection

@article{Lindesmith2003HumanSA,
  title={Human susceptibility and resistance to Norwalk virus infection},
  author={Lisa C. Lindesmith and Christine Moe and S{\'e}verine Marionneau and Nathalie Ruvoen and Xi Jiang and Lauren Lindblad and P. M. Stewart and Jacques Lependu and Ralph A Baric},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={548-553}
}
Infectious diseases have influenced population genetics and the evolution of the structure of the human genome in part by selecting for host susceptibility alleles that modify pathogenesis. Norovirus infection is associated with ∼90% of epidemic non-bacterial acute gastroenteritis worldwide. Here, we show that resistance to Norwalk virus infection is multifactorial. Using a human challenge model, we showed that 29% of our study population was homozygous recessive for the α(1,2… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 315 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…