Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction

@article{Pardo2015HumanSG,
  title={Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction},
  author={Fabi{\'a}n Pardo and Luis Silva and T Estefan{\'i}a Saez and Roc{\'i}o Salsoso and Joaqu{\'i}n Guti{\'e}rrez and Carlos Sanhueza and Andrea Leiva and Luis Sobrevia},
  journal={International Journal of Obesity},
  year={2015},
  volume={39},
  pages={1264-1273}
}
Objective:Human foetal development and growth in an environment of maternal obesity associates with high risk of cardiovascular disease and adverse neonatal outcome. We studied whether supraphysiological gestational weight gain results in human fetoplacental endothelial dysfunction and altered fetoplacental vascular reactivity.Methods:Primary cultures of human umbilical vein endothelial cells (HUVECs) and umbilical vein rings were obtained from pregnant women (112 total of patients recruited, 7… CONTINUE READING
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