Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes

  title={Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes},
  author={Soumaya Kouidhi and Rym Berrhouma and Kamel Rouissi and Slim Jarboui and Marie-St{\'e}phanie Clerget-Froidevaux and Isabelle Seugnet and Fattouma Bchir and Barbara A Demeneix and Hajer Guissouma and Amel Ben Ammar Elgaaied},
  journal={Acta Diabetologica},
Cellular resistance to insulin caused by reduced glucose transport and metabolism is a primary defect leading to the development of metabolic disease. While the etiology of insulin resistance is multifactorial, reduced insulin action is associated with impaired activity of the glucose transporter GLUT4 in insulin-sensitive tissues. Yet, the role of adipose tissue GLUT4 deregulation in the pathogenesis of insulin resistance, obesity, and diabetes is still unclear. In this study, we assessed the… CONTINUE READING

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