Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth

@article{Johnston2010HumanSO,
  title={Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth},
  author={Jennifer Johnston and Yudith Ramos-Valdes and Lee-Anne Stanton and Sadia Ladhani and Frank Beier and Gabriel E. DiMattia},
  journal={Transgenic Research},
  year={2010},
  volume={19},
  pages={1017-1039}
}
Stanniocalcin-1 (STC1) and -2 (STC2) are highly related, secreted, homodimeric glycoproteins that are significantly upregulated by different forms of stress including high phosphate levels. Transgenic mice that constitutively express either human STC1 or STC2 exhibit intra-uterine growth restriction and permanent post-natal growth retardation. STC1 is expressed in chondrocytic and osteoblastic cells during murine development and can enhance differentiation of calvarial cells in culture… CONTINUE READING

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