Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15

@article{Fitzsimmons2003HumanSC,
  title={Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15},
  author={Sara A Fitzsimmons and Hazel Ireland and Nighean I Barr and Andrew P. Cuthbert and James J. Going and Robert F. Newbold and Eric Kenneth Parkinson},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1737-1746}
}
Normal human keratinocytes possess a finite replicative lifespan. Most advanced squamous cell carcinomas (SCCs), however, are immortal, a phenotype that is associated with p53 and INK4A dysfunction, high levels of telomerase and loss of heterozygosity (LOH) at several genetic loci, suggestive of the dysfunction of other mortality genes. We show here that human chromosome 6 specifically reduces the proliferation or viability of a human SCC line, BICR31, possessing LOH across the chromosome. This… CONTINUE READING