Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease.

@article{Brown1994HumanSE,
  title={Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease.},
  author={Paul C Brown and Clarence J. Gibbs and P. E. B. Rodgers-Johnson and David Asher and M P Sulima and Alfred E Bacote and Lev G. Goldfarb and D. Carleton Gajdusek},
  journal={Annals of neurology},
  year={1994},
  volume={35 5},
  pages={513-29}
}
We present a synthesis of clinical, neuropathological, and biological details of the National Institutes of Health series of 300 experimentally transmitted cases of spongiform encephalopathy from among more than 1,000 cases of various neurological disorders inoculated into nonhuman primates during the past 30 years. The series comprises 278 subjects with Creutzfeldt-Jakob disease, of whom 234 had sporadic, 36 familial, and 8 iatrogenic disease; 18 patients with kuru; and 4 patients with… CONTINUE READING
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