Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell.

@article{Lydersen1980HumanspecificNP,
  title={Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell.},
  author={Bjorn K. Lydersen and David E. Pettijohn},
  journal={Cell},
  year={1980},
  volume={22 2 Pt 2},
  pages={489-99}
}
We describe the first example of a predominantly nuclear protein which during mitosis becomes part of the mitotic apparatus. This protein has been termed the nuclear-mitotic apparatus (NuMA) protein. In interphase cells NuMA protein is restricted to the nucleus and is a constituent of isolated nuclear matrices, but in mitotic cells it is observed by indirect immunofluorescence microscopy to be concentrated at the polar regions of the mitotic apparatus. This mitotic localization is dependent on… CONTINUE READING
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