Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells.

@article{Westphal2009HumanspecificIO,
  title={Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells.},
  author={Kera Westphal and Verena Stangl and Michael F{\"a}hling and Henryk Dreger and Andrea Beth Weller and Gert Baumann and Karl Stangl and Silke Meiners},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 11},
  pages={1652-60}
}
Glutathione peroxidase-3 (GPx-3) is a key antioxidant enzyme in the plasma. GPx-3 was previously identified as the major antioxidative enzyme that was induced upon nontoxic proteasome inhibition in endothelial cells. Here, we investigated the determinants of the proteasome inhibitor-induced expression of GPx-3. Nontoxic proteasome inhibition massively upregulates GPx-3 RNA and protein in human umbilical cord vein cells within 24 h. Surprisingly, induction of GPx-3 was species-specific for human… CONTINUE READING