Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

@article{Florio2015HumanspecificGA,
  title={Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion},
  author={Marta Florio and Mareike Albert and E. Taverna and T. Namba and H. Brandl and E. Lewitus and C. Haffner and A. Sykes and F. K. Wong and J. Peters and E. Guhr and Sylvia Klemroth and Kay Pr{\"u}fer and J. Kelso and R. Naumann and I. N{\"u}sslein and A. Dahl and R. Lachmann and S. P{\"a}{\"a}bo and W. Huttner},
  journal={Science},
  year={2015},
  volume={347},
  pages={1465 - 1470}
}
Build the builders before the brain Humans are much smarter than mice—key to this is the relative thickness of the human brain's neocortex. Florio et al. combed through genes expressed in the progenitor cells that build the neocortex and zeroed in on one gene found in humans but not in mice. The gene, which seems to differentiate humans from chimpanzees, drives proliferation of the key progenitor cells. Mice expressing this human gene during development built more elaborate brains. Science… Expand
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