Human slack potassium channel mutations increase positive cooperativity between individual channels.

@article{Kim2014HumanSP,
  title={Human slack potassium channel mutations increase positive cooperativity between individual channels.},
  author={Grace Eun Kim and Jack Kronengold and Giulia Barcia and Imran Habib Quraishi and Hilary C Martin and Edward M. Blair and Jenny C. Taylor and Olivier Dulac and Laurence Colleaux and Rima Nabbout and Leonard K Kaczmarek},
  journal={Cell reports},
  year={2014},
  volume={9 5},
  pages={
          1661-1672
        }
}
Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel that give rise to three distinct forms of epilepsy. All produced many-fold increases in current amplitude compared to the wild-type channel. This could not be accounted for by increases in the intrinsic open probability of individual channels. Rather, greatly… CONTINUE READING
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