Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro.

@article{Cross2008HumanSP,
  title={Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro.},
  author={Sheree E. Cross and Michael D Russell and Ian Southwell and Michael S. Roberts},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2008},
  volume={69 1},
  pages={214-22}
}
The safety of topical application of Australian tea tree Oil (TTO) is confounded by a lack of transdermal penetration data, which adequately informs opinions and recommendations. In this study we applied TTO in its pure form and as a 20% solution in ethanol in vitro to human epidermal membranes from three different donors, mounted in horizontal Franz-type diffusion cells, using normal 'in use' dosing conditions (10 mg/cm2). In addition, we examined the effect of partially occluding the… CONTINUE READING
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