Human skin model containing melanocytes: essential role of keratinocyte growth factor for constitutive pigmentation-functional response to α-melanocyte stimulating hormone and forskolin.

@article{Duval2012HumanSM,
  title={Human skin model containing melanocytes: essential role of keratinocyte growth factor for constitutive pigmentation-functional response to α-melanocyte stimulating hormone and forskolin.},
  author={Christine Duval and Corinne Chagnoleau and F Pouradier and Peggy Sextius and Elodie Condom and Françoise Bernerd},
  journal={Tissue engineering. Part C, Methods},
  year={2012},
  volume={18 12},
  pages={947-57}
}
To study human skin pigmentation in a physiological in vitro model, we developed a pigmented reconstructed skin reproducing the three-dimensional architecture of the melanocyte environment and the interactions of melanocyte with its cellular partners, keratinocytes, and fibroblasts. Co-seeding melanocytes and keratinocytes onto a fibroblast-populated collagen matrix led to a correct integration of melanocytes within the epidermal basal layer, but melanocytes remained amelanotic even after… CONTINUE READING

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