Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

  title={Human skin fibroblasts in vitro differentiate along a terminal cell lineage.},
  author={Klaus Bayreuther and Hans Peter Rodemann and R Hommel and Klaus H. Dittmann and M Albiez and P I Francz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 14},
Secondary mitotic human skin fibroblast populations in vitro underwent 53 +/- 6 cumulative population doublings (CPD) in 302 +/- 27 days. When the growth capacity of the mitotic fibroblasts is exhausted, and if appropriate methods are applied, the fibroblasts differentiate spontaneously into postmitotic fibroblast populations, which were kept in stationary culture for up to 305 +/- 41 additional days. Mitotic and postmitotic fibroblast populations are heterogeneous populations with reproducible… CONTINUE READING

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