Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol.

@article{Smith2000HumanSA,
  title={Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol.},
  author={Clive Smith and Cynthia A. Moore and Eiram N Elahi and Alexandra Smart and Sharon A M Hotchkiss},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={168 3},
  pages={189-99}
}
trans-Cinnamaldehyde and trans-cinnamic alcohol have been commonly reported to cause allergic contact dermatitis (ACD) in humans. Cinnamaldehyde is a more potent skin sensitizer than cinnamic alcohol. It has been hypothesized that cinnamic alcohol is a "prohapten" that requires metabolic activation, presumably by oxidoreductase enzymes such as alcohol dehydrogenase (ADH) or cytochrome P450 2E1 (CYP2E1), to the protein-reactive cinnamaldehyde (a hapten). In this study, the in vitro percutaneous… CONTINUE READING