Human single-stranded DNA binding proteins are essential for maintaining genomic stability

@inproceedings{Ashton2013HumanSD,
  title={Human single-stranded DNA binding proteins are essential for maintaining genomic stability},
  author={Nicholas W. Ashton and Emma Bolderson and Liza Cubeddu and Kenneth J. O’Byrne and Derek J Richard},
  booktitle={BMC Molecular Biology},
  year={2013}
}
The double-stranded conformation of cellular DNA is a central aspect of DNA stabilisation and protection. The helix preserves the genetic code against chemical and enzymatic degradation, metabolic activation, and formation of secondary structures. However, there are various instances where single-stranded DNA is exposed, such as during replication or transcription, in the synthesis of chromosome ends, and following DNA damage. In these instances, single-stranded DNA binding proteins are… CONTINUE READING
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Pavletich NP: BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA

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