Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

@inproceedings{Bandele2011HumanSP,
  title={Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements},
  author={Omari J. Bandele and Xuting Wang and Michelle R. Campbell and Gary S. Pittman and Douglas A. Bell},
  booktitle={Nucleic Acids Research},
  year={2011}
}
p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated tumor suppression. We evaluated the impact of single-nucleotide polymorphisms (SNPs) in p53 response elements (p53RE) on DNA binding and gene expression in response to DNA damage. Using a bioinformatics approach based on incorporating p53 binding strength into a position weight matrix, we selected 32 SNPs in putative and validated p53REs. The… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Transcriptional control of human p53-regulated genes

  • Nature Reviews Molecular Cell Biology
  • 2008
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Fast and accurate short read alignment with Burrows – Wheeler transform

R. Durbin
  • Bioinformatics
  • 2009

Redefining the p53 response element.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 1 EXCERPT