Human single-chain variable fragment that specifically targets arthritic cartilage

  title={Human single-chain variable fragment that specifically targets arthritic cartilage},
  author={Chris Hughes and Bjarne Faurholm and Francesco Dell'Accio and Antonio Manzo and Michael Peter Seed and Noha M Eltawil and Alessandra Marrelli and David Gould and Christina Subang and Adam Al-Kashi and Cosimo de Bari and Paul J. D. Winyard and Yuti Chernajovsky and Ahuva Nissim},
  booktitle={Arthritis and rheumatism},
OBJECTIVE To demonstrate that posttranslational modification of type II collagen (CII) by reactive oxygen species (ROS), which are known to be present in inflamed arthritic joints, can give rise to epitopes specific to damaged cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA) and to establish a proof of concept that antibodies specific to ROS-modified CII can be used to target therapeutics specifically to inflamed arthritic joints. METHODS We used a semisynthetic phage display… CONTINUE READING


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