Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence.

@article{Hogeveen2001HumanSH,
  title={Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence.},
  author={Kevin N Hogeveen and Marja Talikka and Geoffrey L. Hammond},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 39},
  pages={36383-90}
}
Sex hormone-binding globulin (SHBG) is the major sex steroid-binding protein in human plasma and is produced by the liver. Plasma SHBG levels vary considerably between individuals and are influenced by hormonal, metabolic, and nutritional factors. We have now found that a (TAAAA)(n) pentanucleotide repeat, located within an alu sequence at the 5' boundary of the human SHBG promoter, influences its transcriptional activity in association with downstream elements, including an SP1-binding site… CONTINUE READING

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