Human serum reactivity to porcine endothelial cells after antisense-mediated down-regulation of GpIIIa expression.

@article{KearnsJonker1997HumanSR,
  title={Human serum reactivity to porcine endothelial cells after antisense-mediated down-regulation of GpIIIa expression.},
  author={Mary K. Kearns-Jonker and Donald V. Cramer and L A Dane and Joyce Swensson and Leonard Makowka},
  journal={Transplantation},
  year={1997},
  volume={63 4},
  pages={588-93}
}
The hyperacute rejection of vascularized grafts exchanged between discordant species is a result of the binding of preformed natural antibodies to the endothelium of the donor organ, and the subsequent activation of the complement system. Human natural antibodies to pig endothelial cell antigens appear to be predominantly directed at carbohydrate epitopes expressed by a variety of porcine integrins, including GpIIIa. The identification of porcine xenoantigens whose recognition by human natural… CONTINUE READING