Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.

@article{Ghobrial2010HumanSB,
  title={Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.},
  author={Oliver G Ghobrial and Hartmut Derendorf and Jeffrey D. Hillman},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2010},
  volume={41 5},
  pages={658-64}
}
The degree of MU1140 binding to human serum was measured and the effect of serum on MU1140 pharmacodynamics against Streptococcus pneumoniae and Staphylococcus aureus was investigated. 92.7% ± 2.0% of total MU1140 was bound to serum components as determined by ultrafiltration when tested in the concentration range 6.25-200 μg/ml. MIC and time-kill studies were used to study the effect of serum on the dynamics of MU1140. Serum inhibited MU1140 activity against S. pneumoniae but was found to… CONTINUE READING
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