Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.

  title={Human serum binding and its effect on the pharmacodynamics of the lantibiotic MU1140.},
  author={Oliver G Ghobrial and Hartmut Derendorf and Jeffrey D. Hillman},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={41 5},
The degree of MU1140 binding to human serum was measured and the effect of serum on MU1140 pharmacodynamics against Streptococcus pneumoniae and Staphylococcus aureus was investigated. 92.7% ± 2.0% of total MU1140 was bound to serum components as determined by ultrafiltration when tested in the concentration range 6.25-200 μg/ml. MIC and time-kill studies were used to study the effect of serum on the dynamics of MU1140. Serum inhibited MU1140 activity against S. pneumoniae but was found to… CONTINUE READING
4 Citations
26 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 26 references

Effect of protein binding on the pharmacological activity of highly bound antibiotics

  • J. Hillman
  • Antimicrob . Agents Chemother .
  • 2008
Highly Influential
3 Excerpts

Therapeutic potential of type A ( I ) lantibiotics , a group of cationic peptide antibiotics

  • H. Hasper, E. Breukink, +4 authors R. S. Orugunty
  • Curr . Opin . Microbiol .
  • 2008

Structural basis of the drugbinding specificity of human serum albumin

  • F. uttler, L. Tybring, H. Engberg-Pedersen
  • J . Mol . Biol .
  • 2005

Similar Papers

Loading similar papers…