Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.

@article{Pepys1994HumanSA,
  title={Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.},
  author={Mark B Pepys and Thomas W. Rademacher and S Amatayakul-Chantler and Paul D. Williams and G E Noble and Winston L. Hutchinson and Philip N. Hawkins and Stephen R Nelson and Janet Ruth Gallimore and Jeff Herbert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 12},
  pages={5602-6}
}
Human serum amyloid P component (SAP) is a normal plasma protein and the precursor of amyloid P component (AP), a universal constituent of the abnormal tissue deposits in amyloidosis, including Alzheimer disease. We show here that its single N-linked biantennary oligosaccharide does not display the microheterogeneity usually characteristic of glycoproteins. The protein and the glycan structures of AP were also invariant, their resistance to degradation suggesting a role in persistence of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

Similar Papers

Loading similar papers…