Human serum albumin shares the properties of estrocolyone-I, the inhibitor of the proliferation of estrogen-target cells.

@article{Sonnenschein1996HumanSA,
  title={Human serum albumin shares the properties of estrocolyone-I, the inhibitor of the proliferation of estrogen-target cells.},
  author={Carlos Sonnenschein and Ana M. Soto and Cheryl L Michaelson},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1996},
  volume={59 2},
  pages={147-54}
}
The control of cell proliferation by estrogens was examined under the premises of the indirect-negative hypothesis, which states that estradiol cancels the proliferative inhibition exerted by a serum-borne protein on estrogen-target cells. Fractionation protocols resulted in the co-elution of the inhibitory activity with serum albumin. Removal of human albumin (HA) from charcoal-dextran stripped serum by hexyl-S agarose chromatography resulted in a preparation lacking inhibitory effect. HA… CONTINUE READING

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