Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins.

@article{Xu1998HumanSK,
  title={Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins.},
  author={Xia-lian Xu and S Ng and Zhi Li Wu and Dinh Nguyen and S A Homburger and Cynthia Seidel-Dugan and Allen J. Ebens and Yong Luo},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 35},
  pages={22428-34}
}
The semaphorin family contains a large number of secreted and transmembrane proteins, some of which are known to act as repulsive axon guidance cues during development or to be involved in immune function. We report here on the identification of semaphorin K1 (sema K1), the first semaphorin known to be associated with cell surfaces via a glycosylphosphatidylinositol linkage. Sema K1 is highly homologous to a viral semaphorin and can interact with specific immune cells, suggesting that like its… CONTINUE READING

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