Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis

  title={Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis},
  author={J. Bernal and Rosa Luna and {\'A}gueda G. Espina and I. L{\'a}zaro and F. Ramos-Morales and F. Romero and C. Arias and A. Silva and M. Tortolero and Jos{\'e} Antonio Pintor-Toro},
  journal={Nature Genetics},
  • J. Bernal, Rosa Luna, +7 authors José Antonio Pintor-Toro
  • Published 2002
  • Biology, Medicine
  • Nature Genetics
  • The gene PTTG1 (encoding the pituitary tumor–transforming 1 protein) is overexpressed in several different tumor types, is tumorigenic in vivo and shows transcriptional activity. The PTTG1 protein is cell-cycle regulated and was identified as the human securin (a category of proteins involved in the regulation of sister-chromatid separation) on the basis of biochemical similarities with the Pds1p protein of budding yeast and the Cut2p protein of fission yeast. To unravel the function of human… CONTINUE READING
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