Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.

@article{Romero2001HumanSH,
  title={Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.},
  author={Francisco Javier Romero and M C Multon and Francisco Ramos-Morales and Angel Dominguez and Juan Antonio Bernal and J. A. Pintor-Toro and Mar{\'i}a Tortolero},
  journal={Nucleic acids research},
  year={2001},
  volume={29 6},
  pages={1300-7}
}
We have previously isolated the hpttg proto-oncogene, which is expressed in normal tissues containing proliferating cells and in several kinds of tumors. In fact, expression of hPTTG correlates with cell proliferation in a cell cycle-dependent manner. Recently it was reported that PTTG is a vertebrate analog of the yeast securins Pds1 and Cut2, which are involved in sister chromatid separation. Here we show that hPTTG binds to Ku, the regulatory subunit of the DNA-dependent protein kinase (DNA… CONTINUE READING