Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice.

@article{Tietge2002HumanSP,
  title={Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice.},
  author={Uwe J. F. Tietge and Cyrille Maugeais and Sissel Lund-Katz and David S Grass and Frederick C Debeer and Daniel J. Rader},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 7},
  pages={1213-8}
}
OBJECTIVE Plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein (apo)A-I are decreased in inflammatory states. Secretory phospholipase A2 (sPLA2), an acute-phase protein, may play a key role in the pathophysiology of this phenomenon. METHODS AND RESULTS To investigate the effects of sPLA2 on human-like HDL particles in vivo, we generated transgenic mice overexpressing human apoA-I and human sPLA2 (apoA-I/sPLA2 mice). Compared with apoA-I mice, apoA-I/sPLA2 mice had… CONTINUE READING