Human rotavirus in lambs: infection and passive protection.


A human stool filtrate containing rotavirus which was administered orally to gnotobiotic lambs caused diarrhea, virus excretion, development of antibodies to rotavirus, and pathological changes in the villi of the small intestine. Thus, lambs may serve as experimental animals for the study of human rotavirus infections. This model system was used to study… (More)


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@article{Snodgrass1977HumanRI, title={Human rotavirus in lambs: infection and passive protection.}, author={Derke Snodgrass and Carolyn R Madeley and Paula Wells and Kevin Angus}, journal={Infection and immunity}, year={1977}, volume={16 1}, pages={268-70} }