Human right and left colon differ in epithelial cell apoptosis and in expression of Bak, a pro-apoptotic Bcl-2 homologue.

@article{Liu1999HumanRA,
  title={Human right and left colon differ in epithelial cell apoptosis and in expression of Bak, a pro-apoptotic Bcl-2 homologue.},
  author={Lawrence U Liu and Peter R. Holt and V Krivosheyev and Steven F. Moss},
  journal={Gut},
  year={1999},
  volume={45 1},
  pages={45-50}
}
BACKGROUND Propensity to colonic neoplasia differs between the right and left colon. AIMS To examine whether this difference may be related to regional differences in epithelial apoptosis, in expression of a proapoptotic regulatory protein, Bak, and in proliferation. PATIENTS Individuals with no history of colorectal neoplasia. METHODS Archival blocks of colorectal tissues were immunostained for proliferating cells (antibody to Ki-67 antigen), and Bak expression (polyclonal antiserum… CONTINUE READING

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