Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.

@article{Newcomb2008HumanR1,
  title={Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.},
  author={Dawn Catherine Newcomb and Umadevi S Sajjan and Deepti R. Nagarkar and Qiong Wang and Suparna Nanua and Ying Zhou and Christina L. McHenry and Kenneth T Hennrick and Wan C. Tsai and J Kelley Bentley and Nicholas W Lukacs and Sebastian L Johnston and Marc B Hershenson},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={177 10},
  pages={1111-21}
}
RATIONALE Infection with rhinovirus (RV) triggers exacerbations of asthma and chronic obstructive lung disease. OBJECTIVES We sought to develop a mouse model of RV employing RV1B, a minor group serotype that binds to the low-density lipoprotein receptor. METHODS C57BL/6 mice were inoculated intranasally with RV1B, replication-deficient ultraviolet (UV)-irradiated RV1B, or RV39, a major group virus. MEASUREMENTS AND MAIN RESULTS Viral RNA was present in the lungs of RV1B-treated mice, but… CONTINUE READING
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