Human rheumatoid factors bear the internal image of the Fc binding region of staphylococcal protein A

@article{Oppliger1987HumanRF,
  title={Human rheumatoid factors bear the internal image of the Fc binding region of staphylococcal protein A},
  author={I R Oppliger and F A Nardella and Gerard Stone and Mart Mannik},
  journal={The Journal of Experimental Medicine},
  year={1987},
  volume={166},
  pages={702 - 710}
}
The binding specificity of rheumatoid factors (RFs) to human Fc resembles that of some microbial Fc-binding proteins, suggesting conformational similarities in their Fc-binding regions. Using polyclonal chicken antibodies against SPA, we have detected a crossreactive determinant shared by human RFs from different individuals, but not by non-RF IgM and IgG. Chicken anti-SPA was shown to bind to 18 of 19 IgM RFs and 2 of 2 IgG RFs isolated from different individuals. This binding was inhibitable… CONTINUE READING