Human retroviruses in leukaemia and AIDS: reflections on their discovery, biology and epidemiology

  title={Human retroviruses in leukaemia and AIDS: reflections on their discovery, biology and epidemiology},
  author={Abraham Karpas},
  journal={Biological Reviews},
  • A. Karpas
  • Published 1 November 2004
  • Medicine, Biology
  • Biological Reviews
The study of retroviruses has had a profound impact by unveiling an unusual form of viral replication: the multiplication of RNA viruses via a proviral DNA, for which Jan Svoboda provided the experimental model over forty years ago. In 1970 Temin, Mizutani and Baltimore discovered that this group of viruses contains a unique enzyme catalysing the synthesis of a DNA copy of the viral RNA: reverse transcriptase (RT). The discovery of RT has itself had an enormous impact on molecular biology in… 

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