Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants.

@article{Bookstein1988HumanRS,
  title={Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants.},
  author={Robert Bookstein and Eunice Y. Lee and H To and Larry J. Young and Theodore W. Sery and Raymond C. Hayes and Theodore Friedmann and Won Hyuck Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 7},
  pages={
          2210-4
        }
}
A gene in chromosome region 13q14 has been identified as the human retinoblastoma susceptibility (RB) gene on the basis of altered gene expression found in virtually all retinoblastomas. In order to further characterize the RB gene and its structural alterations, we examined genomic clones of the RB gene isolated from both a normal human genomic library and a library made from DNA of the retinoblastoma cell line Y79. First, a restriction and exon map of the RB gene was constructed by aligning… CONTINUE READING

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