Human renal epithelial cells produce the long pentraxin PTX3.

  title={Human renal epithelial cells produce the long pentraxin PTX3.},
  author={Alma J. Nauta and Simone de Haij and Barbara Bottazzi and Alberto Mantovani and Maria C. Borrias and Jan Jaap Aten and Maria P Rastaldi and Mohamed R. Daha and Cees van Kooten and Anja Roos},
  journal={Kidney international},
  volume={67 2},
BACKGROUND Pentraxin 3 (PTX3) is a prototypic long pentraxin with structural similarities in the C-terminal domain to the classical short pentraxins C-reactive protein (CRP) and serum amyloid P component. PTX3 is suggested to play an important role in the innate resistance against pathogens, regulation of inflammatory reactions, and clearance of apoptotic cells. Unlike the classic pentraxins, PTX3 is mainly expressed extrahepatically. The present study was designed to investigate the expression… CONTINUE READING


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