Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone.

@article{Halmos2000HumanRC,
  title={Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone.},
  author={G{\'a}bor Halmos and Andrew V Schally and J{\'o}zsef L. Varga and Artur Plonowski and Zolt{\'a}n R{\'e}k{\'a}si and Tamas Czompoly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 19},
  pages={10555-60}
}
Antagonists of growth hormone-releasing hormone (GHRH) inhibit the proliferation of various human cancers in vitro and in vivo by mechanisms that include apparent direct effects through specific binding sites expressed on tumors and that differ from pituitary human GHRH (hGHRH) receptors. In this study, GHRH antagonist JV-1-38 (20 microgram/day per animal s.c.) inhibited the growth of orthotopic CAKI-1 human renal cell carcinoma (RCC) by 83% and inhibited the development of metastases to lung… CONTINUE READING

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