Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor.

@article{Bisignani1999HumanRC,
  title={Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor.},
  author={G J Bisignani and P J Mclaughlin and S D Ordille and M S Beltz and Mark V Jarowenko and Ian S. Zagon},
  journal={The Journal of urology},
  year={1999},
  volume={162 6},
  pages={2186-91}
}
PURPOSE Peptide growth factors alter cellular events by binding to specific receptors. One group of peptides, the endogenous opioids, is important in the growth of normal and neoplastic tissue. [Met5]enkephalin, also termed opioid growth factor (OGF), is a tonically active inhibitory factor that interacts with the OGF receptor, OGFr, formerly identified as Greek zeta (zeta) and appears to be autocrine produced by human cancer cells. This study examined the hypothesis that OGF directly inhibits… CONTINUE READING

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OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
A variety of natural and synthetic opioids including OGF , opioid antagonists , and opioid antibodies were added to renal cancer cell cultures to determine role of these peptides in renal cell carcinoma .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
A variety of natural and synthetic opioids including OGF , opioid antagonists , and opioid antibodies were added to renal cancer cell cultures to determine role of these peptides in renal cell carcinoma .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
A variety of natural and synthetic opioids including OGF , opioid antagonists , and opioid antibodies were added to renal cancer cell cultures to determine role of these peptides in renal cell carcinoma .
A variety of natural and synthetic opioids including OGF , opioid antagonists , and opioid antibodies were added to renal cancer cell cultures to determine role of these peptides in renal cell carcinoma .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
A variety of natural and synthetic opioids including OGF , opioid antagonists , and opioid antibodies were added to renal cancer cell cultures to determine role of these peptides in renal cell carcinoma .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
cancer cellIs abnormal cell of diseaseRenal Cell Carcinoma
A variety of natural and synthetic opioids including OGF , opioid antagonists , and opioid antibodies were added to renal cancer cell cultures to determine role of these peptides in renal cell carcinoma .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
OGF tonically inhibits renal cancer cell proliferation in tissue culture , and may play a role in the pathogenesis and management of human renal cell cancer .
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