Human recombinant monocyte chemotactic protein and other c‐c chemokines bind and induce directional migration of dendritic cells in vitro

@article{Xu1996HumanRM,
  title={Human recombinant monocyte chemotactic protein and other c‐c chemokines bind and induce directional migration of dendritic cells in vitro},
  author={Luo Ling Xu and Mary Kim Warren and Wendy L. Rose and Wang-hua Gong and Ji Ming Wang},
  journal={Journal of Leukocyte Biology},
  year={1996},
  volume={60}
}
Because dendritic cells (DC) are the most potent antigen‐presenting cells involved in many pathophysiological responses, we investigated the effect of chemokines on the migration of these cells in an effort to determine whether chemokines may contribute to the initiation of immune responses. CD34+ progenitor cells isolated from umbilical cord blood were grown in suspension cultures with cytokines and expanded 50‐ to 100‐fold. A variable proportion of the cells expressed markers consistent with… 
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