Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening.

@article{Novaroli2005HumanRM,
  title={Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening.},
  author={Laura Novaroli and Marianne Reist and Elisabeth Favre and Angelo Carotti and Marco Catto and Pierre-Alain Carrupt},
  journal={Bioorganic & medicinal chemistry},
  year={2005},
  volume={13 22},
  pages={6212-7}
}
Interest in inhibitors of monoamine oxidase type B (MAO B) has grown in recent years, due to their therapeutic potential in aging-related neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. This study is devoted to the use of human recombinant MAO B obtained from a Baculovirus expression system (Supersomes MAO B, BD Gentest, MA, USA) as reliable and efficient enzyme source for MAO B inhibitor screening. Comparison of inhibition potencies (pIC50 values) determined… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…