Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

@article{Dayer1986HumanRI,
  title={Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.},
  author={Jean-Michel Dayer and B de Rochemonteix and Barri B. Burrus and Stephen Demczuk and Charles A Dinarello},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={77 2},
  pages={645-8}
}
The pathogenesis and progression of rheumatoid arthritis involves the production of biologically active lymphokines and monokines. Of these, interleukin 1 (IL-1) has been somewhat of a controversial molecule because it seems to evoke various biological responses in several different tissues. In these studies we demonstrate that three biological properties of human monocyte-derived IL-1 (T-lymphocyte activation and human synovial cell prostaglandin E2 and collagenase production) co-purify. The… CONTINUE READING

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