Human recombinant inhibin A and testosterone act directly at the pituitary to suppress plasma concentrations of FSH in castrated rams.

@article{Tilbrook1993HumanRI,
  title={Human recombinant inhibin A and testosterone act directly at the pituitary to suppress plasma concentrations of FSH in castrated rams.},
  author={Alan John Tilbrook and David Morritz de Kretser and I. J. Clarke},
  journal={The Journal of endocrinology},
  year={1993},
  volume={138 2},
  pages={
          181-9
        }
}
The roles of inhibin and testosterone in the negative feedback control of the secretion of FSH were explored in experiments using castrated rams administered human recombinant inhibin A (hr-inhibin) and testosterone propionate (TP). Two experiments were conducted in the non-breeding season. In experiment 1, two groups of long-term castrated rams (wethers) were treated with an i.v. injection of either vehicle or hr-inhibin in two doses (25 and 50 micrograms) given 2 weeks apart. Plasma… CONTINUE READING
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