Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.

@article{Emerson1988HumanRG,
  title={Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.},
  author={Stephen G Emerson and Yuh Cheng Yang and Steven C. Clark and Michael William Long},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 4},
  pages={1282-7}
}
The hematopoietic stimulatory activities of human recombinant IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF) were directly compared using highly enriched human bone marrow progenitor target cells. IL-3 supported a larger number of erythroid and megakaryocytic progenitor cells than did GM-CSF, while GM-CSF supported more myeloid progenitors. IL-3 directly stimulated the division and migration of primitive erythroid burst forming units, while GM-CSF merely sustained their net… CONTINUE READING
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