Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo.

@article{Rensen1997HumanRA,
  title={Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo.},
  author={Patrick C. N. Rensen and M. Oosten and E Bilt and Matthias Eck and Jan Kuiper and Theo J. C. van Berkel},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 10},
  pages={2438-45}
}
Chylomicrons have been shown to protect mice and rats against a lethal dose of lipopolysaccharide and may serve as a therapeutic means to protect against endotoxemia. However, the requisite of isolation from human lymph hampers pharmaceutical application. Recently, we developed recombinant chylomicrons from commercially available lipids and human recombinant apolipoprotein E. The current study explored the effectiveness of these apoE-enriched emulsions in redirecting LPS from Kupffer cells to… CONTINUE READING