Human recombinant IL-1 alters glucocorticoid receptor function in Reuber hepatoma cells.

@article{Hill1988HumanRI,
  title={Human recombinant IL-1 alters glucocorticoid receptor function in Reuber hepatoma cells.},
  author={Molly R Hill and R. D. Stith and R. E. McCallum},
  journal={Journal of immunology},
  year={1988},
  volume={141 5},
  pages={1522-8}
}
Exposure of Reuber hepatoma cells (RHC) to 30 and 300 fM human rIL-1 (hurIL-1) for 4 h significantly decreased cytosolic glucocorticoid binding. Scatchard analysis indicated that the 30 and 300 fM doses of hurIL-1 significantly decreased the Bmax (maximum number of available binding sites), but did not alter the Kd (affinity of the glucocorticoid receptor for ligand). The decrease in cytosolic glucocorticoid binding, expressed relative to cytosol protein, did not result from increased… CONTINUE READING
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