Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes.

@article{Gonzalez2001HumanRE,
  title={Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes.},
  author={Iris L. Gonzalez and James Sylvester},
  journal={Genomics},
  year={2001},
  volume={73 3},
  pages={255-63}
}
Human rDNA forms arrays on five chromosome pairs and is homogenized by concerted evolution through recombination and gene conversion (loci RNR1, RNR2, RNR3, RNR4, RNR5, OMIM: 180450). Homogenization is not perfect, however, so that it becomes possible to study its efficiency within genes, within arrays, and between arrays by measuring and comparing DNA sequence variation. Previous studies with randomly cloned genomic DNA fragments showed that different parts of the gene evolve at different… CONTINUE READING

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