Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models.

@article{ONeill2015HumanPA,
  title={Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models.},
  author={Jessica O'Neill and Shafaq Sikandar and Stephen B. McMahon and Anthony Henry Dickenson},
  journal={The Journal of physiology},
  year={2015},
  volume={593 17},
  pages={4029-42}
}
Translational research is key to bridging the gaps between preclinical findings and the patients, and a translational model of inflammatory pain will ideally induce both peripheral and central sensitisation, more effectively mimicking clinical pathophysiology in some chronic inflammatory conditions. We conducted a parallel investigation of two models of inflammatory pain, using ultraviolet B (UVB) irradiation alone and UVB irradiation with heat rekindling. We used rodent electrophysiology and… CONTINUE READING
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