Human psychopharmacology of N,N-dimethyltryptamine

  title={Human psychopharmacology of N,N-dimethyltryptamine},
  author={Rick J. Strassman},
  journal={Behavioural Brain Research},
  • R. Strassman
  • Published 1995
  • Medicine, Psychology
  • Behavioural Brain Research
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures. Subjective responses were quantified with a new rating scale, the HRS, which provided better resolution of dose effects than did the biological variables. A tolerance study then was performed, in which volunteers received four closely spaced hallucinogenic doses of… Expand
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Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
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Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans
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N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
  • S. Barker
  • Biology, Medicine
  • Front. Neurosci.
  • 2018
This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brainExpand
Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
DMT behaves as an agonist at both 5- HT2A and 5-HT2A receptors, which suggests the 5-ht2C receptor plays a less prominent role in the action of DMT. Expand
Phenomenology of N,N-Dimethyltryptamine use : a thematic analysis
Abstract—N,N-dimethyltryptamine (DMT) is an endogenous hallucinogeniccompound in the same chemical class as the more common psilocybin and theneurotransmitter serotonin. Despite previous experimentalExpand
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Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale.
Clinical and preliminary quantitative data provide bases for further psychopharmacologic characterization of DMT's properties in humans and may be used to compare the effects of other agents affecting relevant brain receptors in volunteer and psychiatric populations. Expand
Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects.
Dimethyltryptamine can be administered safely to experienced hallucinogen users and dose-response data generated for several measures hypothesized under serotonergic modulatory control may prove useful in psychopharmacological investigations of drug-induced and endogenous alterations in brain function. Expand
The psychedelic model of schizophrenia: the case of N,N-dimethyltryptamine.
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Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors.
DMT has opposing actions on 5-HT receptor subtypes, displaying agonist activity at5-HT1A receptors and antagonist activity at 5- HT2 receptors, and these studies suggest that DMT has antagonistic properties at 4-HT2 receptors. Expand
Human hallucinogenic drug research in the United States: a present-day case history and review of the process.
  • R. Strassman
  • Political Science, Medicine
  • Journal of psychoactive drugs
  • 1991
This article reviews the application process, obstacles and their solutions, and the local and federal issues involved of N,N-dimethyltryptamine (DMT) to humans. Expand
Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat.
  • B. Kovacic, E. Domino
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1976
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  • L. Hollister
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1962
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Antagonism of 5-hydroxytryptamine1A (5-HT1A) receptor-mediated modulation of adenylate cyclase activity by pindolol and propranolol isomers.
The interactions of the stereoisomers of pindolol and propranolol with 5-hydroxytryptamine1A (5-HT1A) binding sites and adenylate cyclase activity were examined in rat hippocampus to suggest that (-)pindolols and (-)propranolols are potent antagonists at 5-HT 1A receptors in rat hippocampal area. Expand
Hallucinogenic N-methylated indolealkylamines in the cerebrospinal fluid of psychiatric and control populations.
The incidence and quantities of dimethyltryptamine and O-methylbufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurologicalExpand
A comparison of the phenomenology of hallucinogens and schizophrenia from some autobiographical accounts.
Comparisons of schizophrenia with drug-induced experiences have proven useful in directing further research aimed at increasing understanding of both phenomena and a comparison of the subjective phenomenology of drug experiences and schizophrenia relying exclusively on autobiographies seems to be nonexistent. Expand